disease

frontotemporal dementia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about frontotemporal dementia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2122Connections

0Hypotheses

0Analyses

38Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	GRN, G3BP1, VCP, MAPT, C9orf72, STING, TREM2, ALS
Therapeutic Agents	levodopa, memantine
KG Connections	624 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    frontotemporal_dementia["frontotemporal dementia"] -->|"involves"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    frontotemporal_dementia["frontotemporal dementia"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    frontotemporal_dementia["frontotemporal dementia"] -->|"affects"| cortex["cortex"]
    style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    frontotemporal_dementia["frontotemporal dementia"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    frontotemporal_dementia["frontotemporal dementia"] -->|"affects"| cerebellum["cerebellum"]
    style cerebellum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    frontotemporal_dementia["frontotemporal dementia"] -->|"affects"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    frontotemporal_dementia["frontotemporal dementia"] -->|"affects"| spinal_cord["spinal cord"]
    style spinal_cord fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TBK1["TBK1"] -->|"risk factor for"| frontotemporal_dementia["frontotemporal dementia"]
    style TBK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    OPTN["OPTN"] -->|"risk factor for"| frontotemporal_dementia["frontotemporal dementia"]
    style OPTN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"activates"| frontotemporal_dementia["frontotemporal dementia"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DNA["DNA"] -->|"interacts"| frontotemporal_dementia["frontotemporal dementia"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"interacts"| frontotemporal_dementia["frontotemporal dementia"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style frontotemporal_dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (496)

Target	Relation	Type	Str
unfolded protein response	involves	pathway	0.90
neurons	affects	cell_type	0.90
cortex	affects	brain_region	0.90
oxidative stress response	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
cerebellum	affects	brain_region	0.80
microglia	affects	cell_type	0.80
spinal cord	affects	brain_region	0.80
lipid metabolism	involves	pathway	0.80
endosome	disrupts	organelle	0.80
epigenetic regulation	involves	pathway	0.80
CRISPR-Cas	involves	pathway	0.80
autophagy pathway	involves	pathway	0.70
oligodendrocytes	affects	cell_type	0.70
temporal lobe	affects	brain_region	0.70
necroptosis	involves	pathway	0.60
endothelial cells	affects	cell_type	0.60
ubiquitin-proteasome	involves	pathway	0.60
complement cascade	involves	pathway	0.60
hippocampus	affects	brain_region	0.60
thalamus	affects	brain_region	0.60
astrocytes	affects	cell_type	0.60
glutamate signaling	involves	pathway	0.60
TGF-beta signaling	involves	pathway	0.60
Notch signaling	involves	pathway	0.60
apoptosis pathway	involves	pathway	0.60
MAPK signaling	involves	pathway	0.60
pyroptosis	involves	pathway	0.60
mitochondrial function	involves	pathway	0.60
glycine	disrupts	neurotransmitter	0.60
frontal lobe	affects	brain_region	0.60
CREB signaling	involves	pathway	0.60
AMPK signaling	involves	pathway	0.60
calcium signaling	involves	pathway	0.60
purinergic signaling	involves	pathway	0.55
glymphatic clearance	involves	pathway	0.55
synaptic plasticity	involves	pathway	0.55
neurotrophin signaling	involves	pathway	0.55

Incoming (1626)

Source	Relation	Type	Str
TBK1	risk_factor_for	gene	0.95
OPTN	risk_factor_for	gene	0.90
ALS	activates	gene	0.90
ALS	regulates	gene	0.90
ALS	associated_with	gene	0.90
ALS	interacts_with	gene	0.90
DNA	interacts_with	gene	0.90
ALS	causes	gene	0.90
RNA	interacts_with	gene	0.90
C9ORF72	causes	gene	0.90
ALS	implicated_in	gene	0.90
FUS	associated_with	gene	0.90
ALS	expressed_in	gene	0.90
FTLD	interacts_with	gene	0.90
TDP-43	implicated_in	protein	0.90
SMPD1	implicated_in	gene	0.90
ALS	modulates	gene	0.90
ALS	accumulates_in	gene	0.90
ALS	disrupts	gene	0.90
TDP-43	associated_with	gene	0.85
tau aggregation propagation	contributes_to	process	0.85
TREM2	implicated_in	gene	0.80
BECN1	activates	gene	0.80
SQSTM1	activates	gene	0.80
MAP1LC3	activates	gene	0.80
LC3	activates	gene	0.80
BECN1	regulates	gene	0.80
SQSTM1	regulates	gene	0.80
LC3	regulates	gene	0.80
OPTN	regulates	gene	0.80
RNA	regulates	gene	0.80
DNA	activates	gene	0.80
ALS	treats	gene	0.80
C9ORF72	activates	gene	0.80
ALS	protects_against	gene	0.80
ALS	biomarker_for	gene	0.80
FTLD	causes	gene	0.80
GRN	causes	gene	0.80
TAU	implicated_in	protein	0.80
polyunsaturated fatty acids	protective_against	compound	0.80
ALS	transported_by	gene	0.80
DNA	disrupts	gene	0.80
TDP43	interacts_with	gene	0.80
PGRN	exacerbates	gene	0.80
APOE4	associated_with	gene	0.75
TDP-43	activates	gene	0.75
TAR	interacts_with	gene	0.75
TDP-43	interacts_with	gene	0.75
TDP-43	protects_against	gene	0.75
stress granules	associated_with	process	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

frontotemporal dementia

Understanding Entity Pages

Wiki Pages (20)

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Novel Therapy Index

primary-progressive-aphasia

calcium-dysregulation-comparison

Corticobasal Degeneration (CBD)

Therapeutics

Neurons — Cell Type Hierarchy